Pharmaceutical Purification Materials

Parameter	Common Range/Type	Typical Example	Function Description
Bonded Phase Type	C18, C8, C4, Phenyl, Cyano (CN), Polar Embedded Phase	C18 (most common), C8 (moderate hydrophobic)	Determines hydrophobic interaction strength. C18 has the strongest hydrophobicity, C8 suits moderate retention, phenyl enhances π-π interaction.
Particle Size (μm)	3-10 (analytical grade), 50-100 (industrial grade)	3μm (high efficiency), 5μm (general), 50μm (preparative)	Smaller particle size increases column efficiency but requires higher pressure; industrial-grade large particle size withstands high pressure, suitable for large-scale purification.
Pore Size (Å)	100-300 (silica matrix)	120Å (small molecules), 300Å (macromolecules)	Pore size ≥ 3 times target molecule diameter ensures mass transfer efficiency; 120Å fits <5kDa molecules, 300Å for antibodies, etc.
Specific Surface Area (m²/g)	150-500	C18: 220m²/g, C8: 170m²/g	Larger surface area increases stationary phase loading and retention capacity.
Carbon Load (%)	6.5-18	C18: 11-17%, C8: 6.5-10%	Carbon chain length and bonding rate determine hydrophobic retention capacity; C18 usually has higher carbon load than C8.
Endcapping	Yes/No (e.g., TMS endcapping, polar embedding)	C18 often uses trimethylsilyl endcapping	Reduces secondary interactions of silanol groups, improves peak shape for basic compounds; polar embedding enhances specific selectivity.
Maximum Operating Pressure	6000-15000 psi (UHPLC)	Conventional HPLC: 6000 psi, UHPLC: 12000 psi	Particle size and packing stability determine pressure tolerance; smaller particle size requires higher pressure.

Types of Pharmaceutical Purification Materials

HP-IC——Ion Exchange Media

Product FeaturesHaipu New Materials' agarose gel-based ion exchange packing materials are specially designed for the purification of biomacromolecules with high biocompatibility requirements, feat...
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HP-C18——Reversed-Phase Chromatography Silica Gel

Haipu New Materials' C18 chromatographic packing employs high-purity spherical silica gel as the matrix, with a particle size specification of 10 μm. It offers pore size parameters including 100 ...
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Unlock Higher Profits with Our Pharmaceutical Purification Materials

Types of Pharmaceutical Purification Materials

HP-IC——Ion Exchange Media

HP-C18——Reversed-Phase Chromatography Silica Gel