HP-C18——Reversed-Phase Chromatography Silica Gel

Application scenarios

Pharmaceutical industry

• Drug development: Widely applied in the separation and purification of drug molecules, synthetic peptides, natural products, as well as acidic, neutral, and alkaline compounds.

Biology and Clinical Fields

• Biological sample pretreatment: Extraction of drug metabolites, lipids, and steroidal compounds from samples such as plasma and urine to reduce matrix interference and enhance detection sensitivity.

• Natural Product Research: Isolation and purification of active components such as propolis extracts, terpenoids, and flavonoids from traditional Chinese medicines to facilitate the development of natural pharmaceuticals.

Chemical Synthesis and Fine Chemicals

• Product purification: In both laboratory preparation and industrial production, synthetic products are purified to remove impurities and by-products.

Three major breakthroughs in the product

Building on extensive expertise in peptide solid-phase synthesis, Hepu has developed a profound understanding of the structural characteristics and purification challenges of peptide molecules. From the design phase onward, its C18 series resins were specifically tailored to address critical requirements for peptide purification, achieving three major breakthroughs:

Molecular Weight Adaptation Optimization

Provide suitable pore size selection and surface modification for molecules of different scales, from short peptides to long-chain polypeptides, to ensure that all types of peptide molecules can achieve the desired separation effect.

Structure Retention and Yield Improvement

Optimized surface chemical properties ensure separation efficiency while maximally preserving the original structure (configuration) of peptides, improving the recovery rate of the target product.

Seamless Process Connection

It forms a good match with the solid-phase synthesis process, helping customers build a complete process chain from synthesis to purification, improving overall process efficiency; at the same time, it also meets the purification requirements of fermentation processes, fitting the usage needs of peptide customers.

Physicochemical Performance Indicators

product superiority

Load capacity versus purity balance:

While ensuring product purity, continuously optimize the payload capacity and enhance batch yield.

Good batch stability:

Strict quality control standards ensure consistency across product batches, providing reliable assurance for process validation.

Wide solvent compatibility:

Adaptable to common solvent systems used in peptide purification, offering flexible process options.

Excellent service life:

The stable mechanical strength and chemical properties extend the service life of the filler, effectively reducing production costs.