HP-2CTC Resin

Name: HP-2CTC Resin
Brand: Jiangsu Haipu Functional Materials Co.,Ltd.

HP-2CTC resin is a polymer used for solid-phase peptide synthesis. In solid-phase peptide synthesis, it bonds with the carboxyl end of amino acids through functional groups to allow peptide chain growth. It can avoid many side reactions and has mild cleavage conditions, making it suitable for fragment synthesis to prepare longer-chain peptides with higher purity. Therefore, HP-2CTC resin should have a large number of stable functional groups to improve yield and fully swell in solvents to reduce steric hindrance and increase the binding rate.

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Characteristics

Extremely sensitive to water and must be handled and stored under inert conditions; if the resin is inactivated, it can be tried to restore activity by treatment with thionyl chloride before use.
This resin can avoid racemization side reactions and DKP side reactions produced by Wang resin, making it very suitable for preparing peptides containing C-terminal Cys, His, Met, Tyr, and Pro residues.
Mild cleavage conditions; usually, 0.5% TFA can release amino acids from the resin.

Applications

Basically, all amino acids can be linked to dichloro resin. When the C-terminal is Cys, Pro, or His, 2-CTC resin is usually selected for forming peptide acids.

Physicochemical Performance Indicators

Parameter	Indicator
Appearance	Light yellow to yellow microspheres
Particle Size (mesh)	100～200
Functional Group	2-Chlorotrityl chloride group
Substitution Degree (mmol/g)	0.4～1.6
Swelling Degree (mL/g)	DCM 3.0～9.0 DMF 3.0～6.0
Cleavage Conditions	1% TFA/5 min
Cleavage Product	Peptide acid

Have Any Questions?

If you have any questions, please don't hesitate to contact us. We're always here to help with ion exchange resins for your business. Haipu is able to produce the product in according to your special needs.

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hpchinaresin@gmail.com

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+86-18168606502
+86-18915626237

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Address

Building 28, Zone D, Phase 5, Bio-pharmaceutical Industrial Park, Suzhou Industrial Park

+86-18915626237