Peptide Solid-Phase Synthesis Carrier Resin Material

The solid-phase synthesis of peptides is widely used in the research field of peptides and proteins, especially in the synthesis of short peptides. With the increasing difficulty and cost of developing new drugs with novel chemical structures, the development of peptide drugs has gradually become a new hotspot in the pharmaceutical industry.

The synthesis technology of peptide drugs is complex, the purification process is tedious, and the requirements for raw materials, carriers, and processes are strict. The emergence of solid-phase synthesis technology for synthesizing peptides and nucleotides has significantly improved the quality and yield of artificially synthesized peptides and nucleotides.

With the rapid growth in demand for peptide and nucleotide drugs in the market, the pharmaceutical industry has also generated a huge demand for porous solid-phase carriers necessary for production processes. Solid phase carrier synthesis is used to immobilize target molecules with carriers. Solid phase carriers can make solid particles, resins, or porous materials with high specific surface area and good chemical stability.

The basic principle of solid-phase synthesis carrier is to contact the reactants with the solid-phase carrier and fix them on the surface of the carrier through chemical bonds or physical adsorption. In this way, when the reactants undergo chemical reactions on the solid-phase carrier, the formation of side reactions and by-products in the solution can be avoided, and the purity and yield of the reaction can be improved. At the same time, the solid-phase carrier can also facilitate the purification and separation steps after the reaction.

The development of solid-phase carriers with different sizes, regular shapes, diverse functional groups, and high functionality is crucial for the production of peptides and nucleotides, directly affecting the molecular weight and yield of the final product, and further determining the purity and yield of drugs.

The peptide solid-phase synthesis carrier product developed by Haipu has mature technology and advanced production process. It has the advantages of high mechanical strength, uniform particle size distribution, uniform distribution of functional group sites, and fast reaction speed. It can provide sufficient connection sites during amino acid coupling, improve the efficiency of amino acid reaction and peptide chain stability, increase product yield, and reduce impurities.

In addition to providing general carrier resins and some coupling agents to peptide synthesis companies, special carriers can also be selectively synthesized according to specific needs, such as carriers connected to amino acids, carriers with special swelling degrees or group loading amounts, carriers loaded with special groups, clearing resins, etc.