Solid Phase Synthesis Carrier for GLP-1 Peptide Drugs

Abstract: The solid-phase synthesis carrier provided by Haipu can be used for the synthesis of peptide drugs and nucleic acid drugs. It has a rich product line, stable overall product quality, and rich application experience.

#GLP-1, a solid-phase synthesis carrier for GLP-1 peptide drugs, is an intestinal derived hormone secreted by intestinal mucosal endocrine cells (L cells) during feeding in humans.

GLP-1 participates in glucose regulation in a glucose concentration dependent manner by stimulating insulin synthesis (pancreatic beta cells) and inhibiting glucagon secretion (pancreatic alpha cells). GLP-1 can promote the regeneration and repair of islet β cells through various mechanisms, especially the role of increasing the number of islet β cells, which provides a development prospect for the treatment and even remission of type 2 diabetes.

The synthesis and purification methods of peptides are important components of peptide pharmaceutical processes. Currently, peptide synthesis methods can be divided into biosynthesis and chemical synthesis methods.

1) Biological synthesis method: With the development of gene recombination technology, in addition to traditional natural extraction methods, commonly used enzymatic hydrolysis and fermentation methods, gene recombination methods have also been gradually applied in peptide synthesis.

2) Chemical synthesis method: Using protective groups to protect the non reactive groups in the raw amino acids, ensuring that the reaction proceeds according to the design direction. Through condensation reactions between amino acids, amino acid connections are extended to obtain peptides with specific sequences. Peptide chemical synthesis methods are divided into liquid-phase synthesis method and solid-phase synthesis method, and the main difference between the two lies in whether a solid-phase carrier is used.

The solid-phase synthesis method requires: resin chemical stability, insolubility in reagents, low steric hindrance, swelling ability, sufficient amino acid extension space, certain mechanical strength, and sufficient connection points; Connecting molecules requires a stable synthesis process, easy subsequent cleavage, and minimal occurrence of side reactions. Carriers can be divided into hydroxyl resins, chloromethyl resins, amino resins, etc. based on the connecting molecules.

The solid-phase synthesis carrier provided by Haipu can be used for the synthesis of peptide drugs and nucleic acid drugs, and has a rich product line; At the same time, the carrier has high mechanical strength, uniform distribution of functional group sites, and fast reaction speed, which can improve the efficiency of amino acid reactions and peptide chain stability in applications. The overall quality of the product is stable and the application experience is rich.